ArticleFrontiers in nutrition2026
Comparison of ultrasound-derived fat fraction and hepatorenal index for quantitative detection of hepatic steatosis: a multicenter MRI-PDFF-referenced study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: MRI-PDFF enables accurate non-invasive quantification of liver fat, but its routine use is limited by cost, availability, and workflow constraints. Ultrasound-derived fat fraction (UDFF) may offer a more accessible quantitative alternative, yet its added value over the conventional hepatorenal index (HRI) remains uncertain when both are judged against the same MRI-PDFF reference standard. Methods: This secondary cross-sectional analysis included 137 participants from a prospectively collected three-center cohort with MRI-PDFF, UDFF, and evaluable HRI measurements. Hepatic steatosis was defined as MRI-PDFF ≥5.0%. Diagnostic performance was compared using ROC analysis and paired DeLong testing, with center-stratified and alternative MRI-PDFF threshold analyses. Measurement reproducibility was evaluated for both UDFF and HRI. Results: MRI-PDFF-defined hepatic steatosis was present in 85 of 137 participants. UDFF showed higher diagnostic discrimination than HRI (AUC, 0.945 [95% CI, 0.907-0.983] vs. 0.779 [95% CI, 0.700-0.859]; paired DeLong Conclusion: In this three-center cohort, UDFF provided stronger and more consistent MRI-PDFF-referenced discrimination for hepatic steatosis than HRI, while both methods showed good measurement reproducibility. UDFF may therefore provide a more robust quantitative ultrasound approach for hepatic steatosis assessment.
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