Evidence map›Paper›PMID 42774374›Full record

ArticleiScience2026

A minimal hybridization capture approach for the parallel enrichment and cost-effective detection of ancient human pathogens.

Arthur Kocher, Andaine Seguin-Orlando, Pierre Clavel, Guillaume Louvel, Richard Jonvel, Stéfan Tzortzis, Michel Signoli, Caroline Costedoat, Ludovic Orlando

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arthur KocherCentre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR 5288, Université de Toulouse, 37 Allées Jules Guesde, 31000 Toulouse, France.
Andaine Seguin-OrlandoCentre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR 5288, Université de Toulouse, 37 Allées Jules Guesde, 31000 Toulouse, France.
Pierre ClavelCentre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR 5288, Université de Toulouse, 37 Allées Jules Guesde, 31000 Toulouse, France.
Guillaume LouvelCentre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR 5288, Université de Toulouse, 37 Allées Jules Guesde, 31000 Toulouse, France.
Richard JonvelAmiens Métropole Service Archéologie Préventive, 2 rue Colbert, 80000 Amiens, France.
Stéfan TzortzisService Régional de l'Archéologie, 21 allée Claude Forbin, 13100 Aix-en-Provence, France.
Michel SignoliAix-Marseille Université, CNRS, EFS, ADES, 13005 Marseille, France.
Caroline CostedoatAix-Marseille Université, CNRS, EFS, ADES, 13005 Marseille, France.
Ludovic OrlandoCentre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR 5288, Université de Toulouse, 37 Allées Jules Guesde, 31000 Toulouse, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The preservation of ancient DNA in archaeological remains enables the identification of past disease agents. However, pathogen DNA is typically highly diluted by host and environmental DNA, limiting detection. Here, we present a proof-of-concept study in which RNA probes for in-solution hybridization capture were designed to improve the detectability of a predefined set of 12 pathogens. We validate the method by reporting enrichment rates of ∼2,000-folds for

Indexed as

cellular neurosciencemolecular neuroscience

Identifiers

PMID42774374
PMCPMC13594432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.