SynthesisFrontiers in cellular and infection microbiology2026
Oral microbiome and lesion-associated microbiological findings in medication-related osteonecrosis of the jaw: a systematic review and evidence map.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Medication-related osteonecrosis of the jaw (MRONJ) may involve microbial colonization, anaerobic organisms, and biofilm formation, but whether it has a reproducible microbial signature remains unclear. We mapped the human microbiological evidence in MRONJ. Methods: The protocol was registered in PROSPERO (CRD420261432571). Reporting followed PRISMA 2020, PRISMA-S, and Synthesis Without Meta-analysis guidance. Six sources were searched from inception in two waves through 25 July 2026, supplemented by citation searching. Original human microbiological studies of MRONJ were eligible. Community-level evidence was classified as core, other MRONJ microbiological evidence as supportive, and evidence from related jawbone conditions as contextual. Five prespecified domains included explicit MRONJ-specific Results: Of 4,044 records, 71 reports representing 67 independent studies were included: 51 MRONJ studies, comprising 13 core and 38 supportive studies, and 16 contextual studies. Community-level findings were not sufficiently comparable for pooling. Among the 51 MRONJ studies, criteria were met by 19 for strict-anaerobe evidence, seven for viral evidence, six for explicit Conclusions: The MRONJ microbiological evidence is methodologically heterogeneous and dominated by observational, lesion-derived studies. Detection proportions varied substantially with method and denominator unit, limiting their interpretation as prevalence estimates. Repeated reports of anaerobic organisms and Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420261432571, identifier CRD420261432571.
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