ArticleMolecular vision2026
Anti-inflammatory action of fluvoxamine in an endotoxin-induced uveitis rat model: Histopathological evidence.
Article in Molecular vision, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Purpose: To investigate the potential protective effects of fluvoxamine (FVX), a selective serotonin reuptake inhibitor with known anti-inflammatory properties, on corneal, limbal, and retinal tissues in a rat model of endotoxin-induced uveitis (EIU), clinical and histopathologic evaluations were performed. Methods: Twenty-eight female Wistar Albino rats were divided into four groups: controls, EIU, EIU + FVX, and FVX (n = 7 per group). EIU was induced by a single intraperitoneal injection of lipopolysaccharide (LPS). FVX or normal saline (NS) was administered 30 min before LPS or NS injection. Clinical ocular inflammation was assessed using slit-lamp biomicroscopy 6 h postinjection. Following euthanasia, enucleated eyes were processed for histopathologic analysis of corneal, limbal, and retinal tissues. Results: Total corneal and epithelial thickness were measured, while limbal and retinal lesions were semiquantitatively graded. The EIU group exhibited significantly increased clinical ocular inflammation scores compared to the control, EIU + FVX, and FVX groups ( Conclusions: FVX significantly reduced clinical signs of ocular inflammation and mitigated histopathologic damage in the cornea, limbus, and retina.
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