ArticleJournal of immunology research2026
Imbalance of Circulating B-Cell Subsets Was Associated With Higher Risk of Relapses in RRMS Patients.
Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
Funding
Abstract
objectivesB-cell aggregates below the meninges have been associated with progression of neurodegeneration in multiple sclerosis (MS). We aimed to investigate the frequency of different B-cell subsets and their relationship with MS severity. Also, we quantified the CXCL13 and neurofilament (NfL) plasma levels.
methodsAccording to the differential expression of IgD, CD38, CD27, HLA-DR, CD138, IL-10, and IL-17, the frequency of different circulating B-cell (CD19
resultsHere, the severity of neurological impairment positively correlated with the percentage of plasmablast (CD138
conclusionsIn summary, our findings suggest that increased circulating anergic or immunogenic B-cell subsets could be candidate biomarkers for low- and high-risk of disease activity, respectively.
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