Evidence map›Paper›PMID 42773805›Full record

Trial reportAnnals of medicine2026

Effects of protein, muscle rehabilitation and trunk neuromuscular electrostimulation in patients with prolonged mechanical ventilation: a prospective, randomized controlled pilot study.

Chun-Yu Lin, Po-Jui Chang, Meng-Jer Hsieh, Yu-Lun Lo, Shih-Wei Lin, Shu-Min Lin, Chen-Yiu Hung, Chun-Yu Lo, Ting-Yu Lin, Allen Chung-Cheng Huang and 7 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05932134 (The Effects of High Protein Supplementation, Core Muscle Rehabilitation and Neuromuscular Electrostimulation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05932134 nacompletednot on this map

The Effects of High Protein Supplementation, Core Muscle Rehabilitation and Neuromuscular Electrostimulation (NMES) Programs on Clinical Outcomes in Patients With Prolonged Mechanical Ventilation (PMV〕

TypeinterventionalSponsorChang Gung Memorial HospitalRan2023 to 2025Enrolled100ConditionsProlonged Mechanical Ventilation, Protein DeficiencyArmsUC + high protein diet (HP), UC + HP + core muscle rehabilitation, UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chun-Yu LinDepartment of Thoracic Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Po-Jui ChangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Meng-Jer HsiehCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yu-Lun LoCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Shih-Wei LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Shu-Min LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chen-Yiu HungCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chun-Yu LoCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ting-Yu LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Allen Chung-Cheng HuangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ko-Wei ChangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Tsai-Yu WangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0001-8213-8393
Shih-Wei HuangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jou-Yun ChangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yu-Feng ChouDepartment of Nutrition, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Chung-Chi HuangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Horng-Chyuan LinCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAttenuating diaphragmatic dysfunction is important in patients with prolonged mechanical ventilation (PMV). The clinical impact of protein supplementation, core muscle rehabilitation and neuromuscular electrostimulation (NMES) in patients with PMV remains unknown. STUDY DESIGN AND

methodsWe conducted a single center, prospective, randomized controlled pilot study for critically ill patients with PMV . All enrolled patients were randomly assigned into four groups: (1) usual care (UC) + high-protein diet (HP); (2) UC + HP + core muscle rehabilitation; (3) UC + HP + core muscle rehabilitation + NMES; and (4) UC. The interventions were maintained for 21 days. Primary outcomes were successful weaning from the ventilator and the duration of mechanical ventilation. Secondary outcomes were length of hospital stay and in-hospital mortality.

resultsA total of 100 patients were enrolled, with 10 in the UC group and 30 each in the other three groups. Nine patients discontinued the trial early. The mean compliance rates of core muscle rehabilitation and NMES were nearly 90%. The patients in group 3 had the highest weaning rate followed by group 2 and group 1, and the difference was significant compared to group 4 (87%, 73%, 67% and 30%,

conclusionCombining high-protein supplementation, core rehabilitation, and NMES is feasible and may facilitate ventilator weaning in PMV patients. Larger multicenter randomized trials are warranted. CLINICAL TRIAL REGISTRATION NUMBER: This trial was registered with ClinicalTrials.gov (NCT05932134, Sep 2023) and is closed to new participants.

Indexed as

Diet, High-ProteinElectric Stimulation TherapyRespiration, ArtificialAdultAgedCritical IllnessFemaleHospital MortalityHumansLength of StayMaleMiddle AgedPilot ProjectsProspective StudiesTreatment OutcomeVentilator Weaningcore muscle rehabilitationneuromuscular electrostimulationprolonged mechanical ventilationProtein supplementationweaning

Identifiers

PMID42773805
PMCPMC13618122

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.