Evidence map›Paper›PMID 42773741›Full record

ArticleChemistry & biodiversity2026

Essential Oil Compositions and Biological Activities of Broussonetia papyrifera Aerial Parts: An Integrated In Vitro and In Silico Study.

Ty Viet Pham, Nguyen Thi Thoa, Nguyen Thi Huong, Le The Hoai, Tran Quang Hai, Shaza W Shantier, Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Vo Thi Dung and 1 more

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ty Viet Pham *Faculty of Chemistry, University of Education, Hue University, Hue, Vietnam.
Nguyen Thi Thoa *Faculty of Chemical Technology, Hanoi University of Industry, Tay Tuu, Hanoi, Vietnam.
Nguyen Thi HuongFaculty of Chemical Technology, Hanoi University of Industry, Tay Tuu, Hanoi, Vietnam.
Le The HoaiFaculty of Chemical Technology, Hanoi University of Industry, Tay Tuu, Hanoi, Vietnam.
Tran Quang HaiFaculty of Chemical Technology, Hanoi University of Industry, Tay Tuu, Hanoi, Vietnam.
Shaza W ShantierDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0002-2543-0248
Nguyen Thi Kim ThanhFaculty of Biology, University of Science, VNU, Nguyen Trai, Hanoi, Vietnam.ORCID https://orcid.org/0000-0003-2948-6385
Phan Hong MinhDepartment of Pharmacology, University of Medicine and Pharmacy, Vietnam National University, Cau Giay, Hanoi, Vietnam.
Huynh Thi Ngoc NiFaculty of Education, Ha Tinh University, Cam Binh, Hatinh, Vietnam.
Vo Thi DungFaculty of Agriculture, Forestry and Fishery, Nghe An University, Nghean, Vietnam.
Ninh The SonInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), Nghia Do, Hanoi, Vietnam.ORCID https://orcid.org/0000-0002-7374-5914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study offers an integrated in vitro and in silico evaluation of the chemical composition and biological activities of the essential oils from Broussonetia papyrifera (L.) Vent. stem bark and leaves, collected in Vietnam. The oils were predominant by oxygenated sesquiterpenes. Major compounds in the stem bark oil included (Z)-dihydro-apofarnesol (13.84%), ishwarane (8.96%), spathulenol (7.87%), palmitic acid (7.58%), and (E)-dihydro-apofarnesol (6.71%), while the leaf oil was characterized by spathulenol (34.78%), n-hexanol (16.64%), ishwarane (7.33%), and (Z)-dihydro-apofarnesol (6.41%). B. papyrifera essential oils showed moderate cytotoxicity against MCF-7 and HepG2 cancer cell lines, with IC

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsBroussonetiaOils, VolatilePlant Components, AerialAnimalsAnti-Inflammatory AgentsArachidonate 5-LipoxygenaseBiphenyl CompoundsCell SurvivalCyclooxygenase 1Cyclooxygenase 2Dose-Response Relationship, DrugDrug Screening Assays, AntitumorHep G2 CellsHumansAnti-Inflammatory AgentsAntineoplastic Agents, PhytogenicAntioxidantsArachidonate 5-LipoxygenaseBiphenyl CompoundsCyclooxygenase 1Cyclooxygenase 2Nitric OxideOils, VolatilePicratesanti‐inflammatory activityBroussonetia papyriferamolecular dockingsesquiterpene alcoholsspathulenol

Identifiers

PMID42773741
PMCPMC13598410

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.