Evidence map›Paper›PMID 42773635›Full record

ArticleSubstance use & misuse2026

Relative Preference of Cannabis, Alcohol, and Nicotine Products Among U.S. Adolescents and Young Adults Who Are Using or Susceptible to Cannabis Use: Insights from a Best-Worst Scaling Study.

Lei Xu, Shiqi Zhang, Mohamed Elsaid, Ce Shang

Abstract read
In one paragraph

Article in Substance use & misuse, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lei XuCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Shiqi ZhangCenter for Tobacco Research, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Mohamed ElsaidDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Ce ShangDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Funding

The impact of excise tax structures for retail marijuana on marijuana consumptionR01DA053294 · NIDA · OHIO STATE UNIVERSITY · PI Ce Shang · 2022 to 2026
$3.4M
NIDA NIH HHS R01 DA053294
6 · The paper itself

Abstract

backgroundThe prevalence of multiple substance use is high among U.S. adolescents and young adults (AYAs), particularly as market shifts with alcohol and cannabis being the most prevalent substances and nicotine vaping displacing cigarette smoking among this population. However, it remains unclear how AYAs evaluate diverse products in terms of preference, addictiveness, and risk.

methodsWe analyzed data from a nationally representative sample of 1,010 U.S. AYAs (aged 15-21) in June 2024 who had used cannabis in the past 30 days or were susceptible to use. Best-worst scaling (BWS) was used to elicit relative preferences across alcohol, tobacco, and cannabis forms. Product-level indices for liking, addictiveness, and risk were analyzed using fractional logistic regression.

resultsCannabis edibles, alcohol, and cannabis flower ranked highest in liking, while tobacco products-especially cigarettes-were less preferred. E-cigarettes and oral nicotine pouches were more favored than cigarettes but remained less liked than cannabis products. Among cannabis forms, cartridges were perceived as both the most addictive and risky, whereas topicals were viewed as least harmful. Regression results showed cannabis oil and most tobacco products were less liked than flowers, while topicals were perceived as less addictive and risky than flowers.

conclusionsAYAs favor cannabis edibles and alcohol while disfavoring traditional tobacco products. Perceptions of risk and addictiveness align with product delivery modes, particularly for high-THC vaping products. These findings suggest both substitution (e.g., away from cigarettes) and complementarity (e.g., cannabis and alcohol), underscoring the need for integrated, multi-product regulatory strategies targeting evolving substance markets.

Indexed as

addiction/dependenceAdolescentscannabis/marijuana/cannabinoidnicotine reductionsocial determinantssubstance use comorbidities

Identifiers

PMID42773635
PMCPMC13673744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.