Evidence map›Paper›PMID 42773631›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Self-Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease.

Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing Li *Department of Ophthalmology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Xi Wan *Department of Ophthalmology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID https://orcid.org/0009-0004-1997-8188
Xinru SuDepartment of Ophthalmology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Zechuan LiDepartment of Ophthalmology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Yue WangInstitute of Heart and Vascular Diseases, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Ying WangInstitute of Heart and Vascular Diseases, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Ruofei LiInstitute of Heart and Vascular Diseases, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Huangzhao WeiDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Jianbin ZhangCollege of Pharmacy, Dalian Medical University, Dalian, China.ORCID https://orcid.org/0000-0001-7848-6379
Shuai WangDepartment of Ophthalmology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID https://orcid.org/0000-0002-9142-6095

Funding

"1 + X" Research Project of the Second Hospital of Dalian Medical University CYQH2024003Chinese Academy of Sciences Medical-Engineering Joint Innovation Fund DMU&DICP UN202516Dalian Excellent Youth Science and Technology Talent Fund 2023RY004Dalian Medical University-Dalian Institute of Chemical PhysicsLiaoning Province Undergraduate Research Training Program for Outstanding Students 2024018
6 · The paper itself

Abstract

Dry eye disease (DED) is a common ocular surface disorder closely associated with mitochondrial dysfunction and excessive accumulation of reactive oxygen species (ROS). However, existing treatments are limited by ocular surface barriers. This study developed an integrated nanomotor-based eye drop system (HPB@Lip@AB) combining self-propulsion, mitochondrial repair, and multiple antioxidant functions. The nanomotor consists of a hollow Prussian blue (HPB) nanozyme core loaded with ammonia borane (AB) as a molecular hydrogen (H

Indexed as

drug deliverydry eye diseasehydrogeninflammationmitochondrial dysfunctionnanomotor

Identifiers

PMID42773631
PMCPMC13598384

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.