ArticleYonsei medical journal2026
Association between Early-Onset Metabolic Diseases and Adverse Mental Health Conditions: A Nationwide Cross-Sectional Study.
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThough metabolic diseases increasingly affect younger populations, their mental health implications remain poorly understood. We examined associations between age at metabolic disease diagnosis and mental health conditions, comparing early-onset (age <40 years) and late-onset (age ≥40 years) cases. MATERIALS AND
methodsWe analyzed the 2014-2023 Korea National Health and Nutrition Examination Survey. Participants reported physician-diagnosed hypertension, diabetes, or dyslipidemia, with age at diagnosis. Mental health conditions included depression, perceived stress, and suicidality. Depression was assessed using the Patient Health Questionnaire-9, perceived stress through self-reported daily experiences, and suicidality as the presence of suicidal ideation, planning, or attempts within the past year. Associations were examined using multiple logistic regression with Bonferroni correction.
resultsEarly-onset hypertension [odds ratio (OR)=2.67; 95% confidence interval (CI): 1.91-3.74] and dyslipidemia (OR=2.55; 95% CI: 1.71-3.79) showed higher odds of depression compared to undiagnosed and late-onset cases (
conclusionEarly-onset metabolic diseases showed stronger associations with adverse mental health conditions than late-onset cases, with patterns suggesting these associations were not primarily explained by disease duration. While the cross-sectional design limits causal inference, mental health screening in early-onset metabolic disease care could be considered.
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