ArticleParasites & vectors2026
Insecticide susceptibility and knockdown resistance (Kdr) mutations (F1534C and V1016I) in Aedes aegypti populations from Dar es Salaam, Tanzania.
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDengue, Zika and chikungunya are Aedes-borne arboviruses that pose a major global public health threat. In the absence of effective treatments or universally available vaccines, disease control in sub-Saharan Africa relies primarily on insecticidal vector control. However, sustained insecticide application imposes selection pressure for insecticide resistance that compromises intervention effectiveness. This study assessed the insecticide resistance profile and knockdown resistance of Aedes aegypti populations in Dar es Salaam, Tanzania.
methodsPhenotypic resistance of Ae. aegypti was evaluated using WHO-recommended adulticide and larvicide susceptibility bioassays at discriminating concentrations. F
resultsAedes aegypti populations from Ilala and Temeke districts of Dar es Salaam demonstrated phenotypic resistance to Pyrethroid: permethrin, deltamethrin, alpha-cypermethrin, lambda-cyhalothrin, and organochlorine, with adult mortality rates below 20% and 5%, respectively, while remaining susceptible to organophosphates and carbamates. In Kinondoni, resistance was observed across all classes except carbamates, and pre-exposure to piperonyl butoxide (PBO) increased pyrethroids mortality to an average of 40%. The LD
conclusionsAedes aegypti populations from Dar es Salaam show widespread resistance to pyrethroids, and organochlorines. There was evidence of metabolic involvement suggested by partial restoration of susceptibility to pyrethroids through pre-exposure to PBO. A twofold increase in LD
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