ReviewBreast cancer research : BCR2026
Unveiling CCL5: the master regulator of breast cancer progression and immune evasion.
Review in Breast cancer research : BCR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
CCL5, abbreviated from C-C motif chemokine ligand 5, exerts diverse regulatory effects on both the initiation and progression of breast cancer (BC), making it a focal point of extensive research within the field. By enhancing the growth, invasive ability, and metastatic potential of BC cells, simultaneously recruiting and polarizing immunosuppressive cell populations, CCL5 actively reshapes the tumor immune microenvironment. Furthermore, elevated CCL5 levels are strongly linked to particular clinicopathological parameters, worse clinical outcomes, and a higher likelihood of recurrence in BC, suggesting its value in early diagnosis and prognosis. Current preclinical studies targeting the CCL5/CCR5 axis have demonstrated notable efficacy in inhibiting the progression of BC. This article explores how CCL5 contributes to BC progression and elucidates its regulatory mechanisms, providing theoretical support and potential targets for innovative therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.