Evidence map›Paper›PMID 42773443›Full record

ArticleJournal of nanobiotechnology2026

Breaking the ROS inflammation loop: a hierarchical nanozyme natural enzyme cascade for acetaminophen induced acute liver injury.

Mengmeng Dong, Xiaomin Huang, Kaiqiang Li, Xiaorong Zhu, Tingting Hu, Xiaohuan Guo, Ke Hao, Fei Kong, Mei Yang, Ning Hu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengmeng Dong *Laboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Xiaomin Huang *Eye Institute, Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, 200000, China.
Kaiqiang LiLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Xiaorong ZhuLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Tingting HuLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Xiaohuan GuoLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Ke HaoLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Fei KongLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.
Mei YangEye Institute, Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Fudan University, Chinese Academy of Medical Sciences, Shanghai, 200000, China.
Ning HuGeneral Surgery Department, Children's Hospital, School of Medicine, Zhejiang University, National Clinical Research Center for Children's Health, Hangzhou, 310052, China.
Yingwei WangCenter for Laboratory Medicine, Precision Medicine Center, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College, Taizhou, 317200, China. wyw724@163.com.
Lisen LuNHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan, 571199, China. hy2025061@muhn.edu.cn.
Zhen WangLaboratory Medicine Center, Department of Transfusion Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. yuchen6046@163.com.

Funding

Postdoctoral Scientific Research Start-up Fund C-2023-BSH33
6 · The paper itself

Abstract

Acetaminophen (APAP) induced acute liver injury (ALI) is driven by a self amplifying cascade of reactive oxygen species (ROS) and lipid peroxidation, yet current therapies fail to interrupt this pathological loop. Here we engineer a liver targeted hierarchical nanozyme, SOD@ZIF-8/Mn

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryInflammationReactive Oxygen SpeciesSuperoxide DismutaseAnimalsCell LineHydrogen PeroxideLipid PeroxidationLiverMaleMiceMice, Inbred C57BLOxidative StressAcetaminophenHydrogen PeroxideReactive Oxygen SpeciesSuperoxide DismutaseAcute liver injuryCatalytic hierarchyMetal-organic frameworksROS cascade interruptionSOD

Identifiers

PMID42773443
PMCPMC13595542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.