ArticleGeroScience2026
Exergame as medicine? Functional brain adaptations linked to cognitive changes in neurocognitive disorders: exploratory randomized controlled trial.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Tailored multidomain lifestyle modifications are recommended for reducing dementia risk in mild neurocognitive disorder (mNCD). However, evidence of their capacity to modify disease trajectories and restore functional brain abnormalities remains limited. We aimed to explore functional brain adaptations and correlate underlying cognitive improvements in response to a personalized "exergame as medicine" program ("Brain-IT") for secondary mNCD prevention. Participants were randomized to 12 weeks home-based "Brain-IT" (physical-motor-cognitive with integrated biofeedback breathing training; 120 min/week, moderate intensity) + usual care or usual care alone. Resting-state functional connectivity at the seed(hippocampus)-to-voxel level and task-based full-factorial analysis of variance for functional activation (Blood Oxygenation Level Dependent signal responses) and their correlations with episodic memory performance were analyzed. Data from 32 mNCD participants (71.9 ± 8.1 years; 28% females) with mostly biomarker-supported Alzheimer's etiology (57%) were analyzed. Key findings were significantly (p < 0.0001) reduced hippocampus hyperactivation during memory encoding (partial η
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.