ArticleAging clinical and experimental research2026
Time to pacemaker insertion in older adults: A perspective on mortality and functional outcomes.
Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Pacemaker insertion is common in older adults, yet the implications of procedural delays remain unclear. Nguyen and colleagues reported that longer time to implantation was associated with increased mortality over nearly five years. While this contribution is valuable, several methodological considerations warrant scrutiny before causal interpretations can be drawn. Infection may drive delay rather than result from it, as suggested by elevated neutrophils in the delayed group. Deconditioning, proposed as the mediating mechanism, was not directly measured. Residential aged care admission as a proxy for functional decline is influenced by social and caregiver factors independent of patient function. The 48‑hour threshold appears data‑driven rather than clinically justified. Finally, the absence of baseline frailty measures leaves residual confounding. Addressing these considerations would strengthen causal inference and refine clinical strategies.
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