ArticleJournal of neuro-oncology2026
Radiation-induced cranial meningiomas are associated with earlier relapse: a propensity score-matched cohort study.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial meningiomas may be induced after radiation exposure, for example following radiotherapy for CNS malignancies. However, data on their clinical characteristics and risk factors for recurrence remain limited. This study aimed to evaluate clinical features and independent predictors of progression-free survival in radiation-induced meningiomas compared to sporadic tumors.
methodsAll cases of radiation-induced (RI) intracranial meningiomas that underwent tumor resection at our institution between 2007 and 2023 were identified. Patients were matched to non-radiation-induced controls by propensity score using age, WHO grade, and Simpson grade as covariates (1:5 ratio). Demographics, tumor characteristics, and outcomes were compared. Survival was analyzed using Kaplan-Meier curves and Cox regression.
resultsA total of 39 RI meningioma cases were matched to 195 non-exposed controls. After matching, there were no significant differences in age, WHO grade, or Simpson grade between groups, confirming adequate baseline balance. Prior cranial surgery was more frequent in the RI group (38.5% vs. 4.1%; p < 0.001), and adjuvant radiotherapy was more commonly administered (33.3% vs. 11.3%; p < 0.001). Relapse rate was significantly higher in RI tumors (28% vs. 17%; p = 0.001). In multivariate Cox regression, RI tumor status (HR 2.1; 95% CI 1.02-434; p = 0.04) and complete resection (HR 0.29; 95% CI 0.15-0.54; p < 0.001) were independent predictors of progression-free survival.
conclusionRadiation-induced meningioma status was associated with shorter progression-free survival following propensity score matching and multivariable adjustment. Complete resection was associated with improved PFS, supporting maximal safe resection when clinically feasible. However, residual measured and unmeasured confounding cannot be excluded, and the present findings should not be interpreted as evidence of intrinsically more aggressive tumor biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.