ArticleJournal of ultrasound2026
Conventional sonographic phenotype of thyroid oncocytic neoplasms: a pathology-confirmed comparative study.
Article in Journal of ultrasound, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo describe the conventional sonographic features of oncocytic thyroid neoplasms (OTNs) and compare them with those of papillary thyroid carcinoma (PTC), nodular goiter (NG), and three follicular-pattern comparator groups: follicular adenoma (FA), follicular thyroid carcinoma (FTC), and follicular variant of papillary thyroid carcinoma (FVPTC).
methodsThis retrospective study included 344 pathology-confirmed lesions: 41 OTNs, 110 PTCs, 90 NGs, 45 FAs, 24 FTCs, and 34 FVPTCs. Two radiologists independently re-reviewed stored preoperative ultrasound images while blinded to histopathologic diagnoses. Because the original reports did not consistently document C-TIRADS categories, they were reconstructed post hoc from feature-level descriptors. Feature-specific Firth logistic regression models adjusted for age, sex, and maximum lesion diameter, used size-matched sensitivity analyses; 1:1 matching with a 5-mm caliper.
resultsOTNs were larger than PTC, NG, and FVPTC lesions (median maximum diameters: 25.0, 7.0, 9.0, and 10.0 mm, respectively; P < 0.001) but similar in size to FA and FTC lesions. They were commonly wider than tall (100.0%), had smooth margins (80.5%), were isoechoic (65.9%), and were hypervascular (70.7%). After adjustment, all six prespecified features were associated with OTN versus PTC. Compared with NG, smooth margins (aOR, 3.84; 95% CI, 1.30-13.14; P = 0.014) and is echogenicity (aOR, 3.36; 95% CI, 1.19-9.69; P = 0.022) remained associated with OTN. Compared with the pooled follicular-pattern comparator group (FA, FTC, and FVPTC), smooth margins and absence of focal echogenic foci remained associated with OTN (aORs, 3.71 and 2.55; P = 0.002 and 0.022, respectively), but these associations were attenuated after lesion-size matching.
conclusionsIn this surgically selected cohort, OTNs showed several recurring conventional sonographic features, but their appearance overlapped substantially with follicular neoplasms and NG. Ultrasound may raise preoperative suspicion for an oncocytic phenotype but cannot distinguish oncocytic adenoma from oncocytic carcinoma.
Indexed as
Identifiers
42773292What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.