ArticleBritish journal of cancer2026
Reproductive factors and the expression of stromal markers in benign breast biopsy samples.
Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundWe examined the associations of several reproductive factors with expression of stromal fibroblast markers αSMA, TNC, FAP, S100A6, and MMP14.
methodsWe included 694 cancer-free women with biopsy-confirmed incident benign breast disease within the Nurses' Health Study II. Breast cancer risk factor data were obtained from biennial questionnaires. Immunofluorescence of stromal markers was completed on tissue microarrays. For each core, % positivity was quantified with inForm v2.6.0. Generalized linear regression was used to examine the associations of reproductive factors with log-transformed positivity for each marker.
resultsIn multivariate analysis, nulliparous status showed a suggestive positive association with TNC expression (β = 0.79, 95% CI -0.10, 1.68, p = 0.08) but was not associated with the other stromal markers (all p > 0.10). No associations were seen for number of children, age at 1st birth, breastfeeding, continuous age at menarche, time between menarche and age at first birth, and time since last birth with any of the markers' expression. Categorical age at menarche showed a suggestive positive association with MMP14 (p-trend = 0.07).
conclusionOur findings suggest that nulliparous status and age at menarche may be associated with the expression of stromal fibroblast activation markers TNC and MMP14, respectively. Further studies are needed to confirm these findings.
Identifiers
42773217What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.