Evidence map›Paper›PMID 42773212›Full record

ArticleNature medicine2026

Blood proteomics of menopause map to brain aging and dementia risk.

Madeline Wood Alexander, Jennifer S Rabin, Michelle Caunca, Allesandra Iadipaolo, Louisa Cornelis, Ria Warrier, Keenan A Walker, Nina Miolane, Veronica Augustina Bot, Brendan Wood and 17 more

Abstract read
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In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Madeline Wood AlexanderHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada. madeline.wood@sri.utoronto.ca.ORCID http://orcid.org/0000-0003-4598-0201
Jennifer S RabinHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4754-2221
Michelle CauncaDepartment of Neurology, Neurovascular Division, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Allesandra IadipaoloDepartment of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA.
Louisa CornelisDepartment of Physics, University of California, Broida Hall, Santa Barbara, CA, USA.
Ria WarrierLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
Keenan A WalkerLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5989-9853
Nina MiolaneAnn S. Bowers Women's Brain Health Initiative, University of California, Santa Barbara, CA, USA.
Veronica Augustina BotThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0008-5060-1142
Brendan WoodHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Hamilton Se-Hwee OhNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-8192-7593
Tony Wyss-CorayThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5893-0831
Albert PhamDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Julia BorgerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Valentina DiazDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Emily W PaolilloDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Joel KramerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Laura PritschetAnn S. Bowers Women's Brain Health Initiative, University of California, Santa Barbara, CA, USA.
Caitlin TaylorDepartment of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA.
Matthew S PanizzonCenter for Behavior Genetics of Aging, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Ramiro Eduardo Rea ReyesWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Marisa N DenkingerBanner Sun Health Research Institute, Sun City, AZ, USA.
Nicholas J AshtonBanner Sun Health Research Institute, Sun City, AZ, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-8501-545X
Emily G JacobsDepartment of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0003-0001-5096
Rowan Saloner *Ann S. Bowers Women's Brain Health Initiative, University of California, Santa Barbara, CA, USA. rowan.saloner@ucsf.edu.ORCID http://orcid.org/0000-0002-1351-6183
Kaitlin B Casaletto *Ann S. Bowers Women's Brain Health Initiative, University of California, Santa Barbara, CA, USA. kaitlin.casaletto@ucsf.edu.ORCID http://orcid.org/0000-0001-5000-7604

Funding

NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)UE5NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott Andrew Josephson · 2024 to 2026
$2.6M
NINDS NIH HHS UE5 NS070680
6 · The paper itself

Abstract

Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = 80 rigorously staged (STRAW+10) pre-, peri- and postmenopausal women (aged 43-58 years) with serum NULISAseq proteomics, we show that spontaneous menopause is characterized by dysregulation in inflammatory, synaptic, metabolic and Alzheimer's disease biologic processes, which tracked more strongly with hormones than with age. Validation analyses in age-matched pre-/peri- and postmenopausal women (n = 2,814) with plasma Olink proteomics replicated the observed proteomic shifts and revealed broader menopause-related upregulation of inflammatory and catabolic processes plus accelerated organ and cell aging, including brain aging. In four independent cohorts of older women (average age, 60.7-72.1 years; total n = 11,925), higher menopause proteomic scores associated consistently with cognitive aging and dementia risk. The molecular signatures of menopause may inform the selection of biomarkers or therapeutic targets for brain health in midlife women.

Identifiers

PMID42773212

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.