Evidence map›Paper›PMID 42773181›Full record

ArticleLeukemia2026

C3- and C5-deficient murine cells exhibit severe mitochondrial defects, indicating a pivotal, novel role of innate immunity in regulating hematopoiesis at the electron transfer chain level.

Michalina Kazek, Damian Wojdalski, Adrian Konopko, Patrycja Kieszek, Agnieszka Lukomska, Kannathasan Thetchinamoorthy, Hanna Nieznańska, Magdalena Świadek, Emilia Waraksa-Zasada, Janina Ratajczak and 2 more

Abstract read
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In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michalina KazekCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Damian WojdalskiCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Adrian KonopkoCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Patrycja KieszekCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Agnieszka LukomskaCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Kannathasan ThetchinamoorthyCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Hanna NieznańskaLaboratory of Electron Microscopy of the Center for Translational Research, Nencki Institute of Experimental Biology, Warsaw, Poland.
Magdalena ŚwiadekLaboratory of Electron Microscopy of the Center for Translational Research, Nencki Institute of Experimental Biology, Warsaw, Poland.ORCID http://orcid.org/0009-0007-7708-7844
Emilia Waraksa-ZasadaCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Janina RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Magdalena KuciaCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland.
Mariusz Z RatajczakCenter for Preclinical Studies and Technology, Laboratory of Regenerative Medicine at Medical University of Warsaw, Warsaw, Poland. mzrata01@louisville.edu.ORCID http://orcid.org/0000-0002-0071-0198

Funding

Narodowe Centrum Nauki (National Science Centre) OPUS grant UMO-2022/45/B/NZ6/00475
6 · The paper itself

Abstract

We recently reported that the functional intracellular complement network, known as the complosome, is expressed in hematopoietic stem/progenitor cells (HSPCs). In our recent work, murine lineage-negative (Lin

Identifiers

PMID42773181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.