Evidence map›Paper›PMID 42772937›Full record

ArticleImmunoHorizons2026

Integrative scRNA-seq and scTCR-seq analyses decode dual TCR γδ T-cell characteristics in human and mouse.

Huifang Wang, Yuanyuan Xu, Naixin Cao, Qingqing Ma, Jun Li, Kai Quan, Xinsheng Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ImmunoHorizons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Huifang WangDepartment of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.
Yuanyuan XuDepartment of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.
Naixin CaoDepartment of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.
Qingqing MaAerospace Hospital of Zunyi Medical University (Hospital 417), Clinical laboratory, Zunyi, China.
Jun LiDepartment of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.
Kai QuanDepartment of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.
Xinsheng YaoDepartment of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.

Funding

Guizhou Provincial Hundred level Talent FundNational Natural Science Foundation of China 82160279
6 · The paper itself

Abstract

The clonal selection theory of "one lymphocyte expresses one type of antigen receptor" has been challenged and complemented by the concept of dual receptor lymphocytes. However, the proportion, source, and characterization of dual TCR γδ T cells have not been determined. Using single-cell RNA plus single-cell TCR sequencing, we discovered a high proportion of dual γδ T cells datasets of the human thymus and mouse spleens. We observed differences in the proportion of single and dual TCR from γδ T cells, the types of δ and γ pairings, the frequency of TRDV and TRGV genes, and the expression of mRNA molecules across various γδ T-cell subgroups. Additionally, we investigated the likely genesis of dual TCR mRNA based on its compositional properties. This work provides a new perspective and scheme for the study of γδ T cells.

Indexed as

Receptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAnimalsComplementarity Determining RegionsHumansMiceRNA, MessengerRNA-SeqSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisSpleenThymus GlandComplementarity Determining RegionsReceptors, Antigen, T-Cell, gamma-deltaRNA, Messengerallelic inclusion (exclusion escape)CDR3 repertoiredual TCRssingle-cell RNA + TCR sequencingγδ T cell

Identifiers

PMID42772937
PMCPMC13597122

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.