ReviewImmunoHorizons2026
Mostly getting along -Borrelia burgdorferi and its manipulation of the host immune system.
Review in ImmunoHorizons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Lyme disease is caused when mammalian hosts not part of the sylvatic life cycle, including humans, are infected with Borrelia burgdorferi (Bb) following the bite of an Ixodes tick. Ticks and natural mammalian host reservoirs, including rodents, however, are largely disease tolerant, despite Bb establishing persistent infection. We explore the complex and ongoing interplay between Bb and the immune system. We discuss how Bb infection-induced innate responses seem maladapted to this extracellular bacterial infection, perhaps explaining why CD4+ T cells are ineffective contributors to Bb infection control. While B cell responses critically control Bb tissue burden and disease development they cannot clear the infection, showing a bias towards ongoing plasmablast responses and a lack of functional germinal centers. Identifying the mechanisms that hinder effective immune clearance of Bb may lead to new approaches for the treatment of Lyme Disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.