ArticleBMJ open2026
Implementation and performance of a national pilot programme for eliminating mother-to-child transmission of syphilis: a retrospective cross-sectional study in China.
Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSyphilis remains a significant global health burden, with congenital syphilis (CS) posing a major threat to child health. China has implemented the elimination of mother-to-child transmission (EMTCT) programme for syphilis through integrated strategies. However, few studies have analysed granular data along the entire cascade of care to identify specific bottlenecks.
objectiveWe aimed to characterise the implementation status of integrated interventions in Baoan District, Shenzhen, and to identify risk factors associated with suboptimal indicators.
methodsThis retrospective cross-sectional study used data from the information system for the prevention of mother-to-child transmission of syphilis in Baoan District (2017-2024). Indicators were compared between the pre-practice (2017-2018) and post-practice (2019-2024) periods using Pearson's
resultsA total of 752 pregnant women with syphilis and 769 exposed liveborn infants were finally included. Compared with the pre-practice period, significant upward trends were observed in the post-practice period across all process indicators (all p<0.05), while no statistically significant decline in live birth CS incidence was observed between the two periods (2.92 vs 1.59 per 100 000 live births, p=0.70). During 2019-2024, antenatal screening coverage (
conclusionsEMTCT process indicators showed favourable trends during the integrated implementation period in Baoan District. However, gaps in achieving the treatment adequacy target highlight critical bottlenecks. Targeted interventions for high-risk populations, including ethnic minorities, women with late or insufficient antenatal care and those with untested partners, are essential to further achieve EMTCT goals.
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