Evidence map›Paper›PMID 42772685›Full record

ArticleThe Journal of nutrition2026

EAT-Lancet Diet-Associated Serum Metabolites Are Linked to Cardiovascular Disease and Mortality.

Wanjin Guan, Jiaqi Yang, Jingsha Chen, Bing Yu, Valerie K Sullivan, Casey M Rebholz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanjin GuanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Jiaqi YangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Jingsha ChenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Bing YuDepartment of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX, United States.
Valerie K SullivanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: crebhol1@jhu.edu.

Funding

THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
Discovery, Replication, and Validation of Biomarkers of the DASH Diet and HypertensionR01HL153178 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI REBHOLZ, CASEY MARIE · 2021 to 2024
$3.1M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS R01 HL153178
6 · The paper itself

Abstract

backgroundHigher adherence to the EAT-Lancet diet is associated with lower risk of cardiovascular disease (CVD) and all-cause mortality. Metabolomic profiling can identify biomarkers underlying these associations.

objectivesWe aimed to investigate metabolomic markers of the EAT-Lancet diet and risk of CVD and all-cause mortality.

methodsWe analyzed 2 independent subgroups of Atherosclerosis Risk in Communities study participants (n

resultsTwenty-nine (23 positively and 6 inversely) of 359 metabolites were associated with the PHDI score. During a median follow-up of 24 y for CVD and 29 y for mortality, 1352 incident CVD cases and 2088 deaths occurred. Four PHDI-related metabolites were associated with incident CVD or all-cause mortality. Glycerate was associated with lower risks of these outcomes [incident CVD hazard ratio (HR) = 0.89, 95% confidence interval (CI): 0.82, 0.96; all-cause mortality HR = 0.86, 95% CI: 0.81, 0.91]. Indolepropionate was linked to lower risk of all-cause mortality, and 1-docosahexaenoylglycerophosphocholine (22:6n3) was associated with lower risk of incident CVD. O-methylcatechol sulfate was positively associated with both outcomes.

conclusionsIn a community-based cohort of United States adults, 29 metabolites are associated with the PHDI score. Four of these metabolites are associated with incident CVD or all-cause mortality, highlighting potential mechanisms of the health impacts of the EAT-Lancet diet.

Indexed as

cardiovascular diseasedeathEAT-Lancet dietmetabolitesPlanetary Health Diet Index

Identifiers

PMID42772685
PMCPMC13654595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.