ArticleAnaesthesia, critical care & pain medicine2026
Comparative epidemiology of intraoperative hypotension and hypoxemia across three large retrospective cohorts.
Article in Anaesthesia, critical care & pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntraoperative hypotension is associated with morbidity and mortality, but comparable evidence for intraoperative hypoxemia remains sparse. Their joint epidemiology remains unclear.
methodsWe analyzed three retrospective noncardiac surgical cohorts (INSPIRE, MOVER, MSHS) totaling 165,646 cases. We defined binary hypotension as mean arterial pressure (MAP) <65 mmHg for >10 minutes, and hypoxemia as SpO
resultsHypotension prevalence (12.7-28.8%) exceeded hypoxemia prevalence (2.3-4.9%); they co-occurred in <1% of cases. Hypotension clustered near induction, whereas hypoxemia had bimodal onset near induction and emergence. The two events had largely distinct preoperative associations. After mutual adjustment, binary hypoxemia was associated with all three outcomes, and binary hypotension with ICU admission and mortality but not AKI. TWA-MAP and TWA-SpO
conclusionsHypotension and hypoxemia rarely co-occurred and had distinct preoperative associations, but each was independently associated with outcomes. Further research should evaluate hypoxemia burden.
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