ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026
Reversal of injury-induced fibrosis and anal sphincter muscle dysfunction by sFRP2 in rabbits.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anal sphincter injury is a major cause of anal incontinence (AI), and current treatments rarely restore anal sphincter muscle function. Secreted frizzled-related protein 2 (sFRP2) may promote muscle regeneration and reduce fibrosis, but its ability to reverse the established external anal sphincter (EAS) fibrosis and restore function is not known. This study examined whether sFRP2 promotes functional and structural recovery in a rabbit model of established EAS muscle fibrosis. Adult female rabbits underwent EAS myotomy and, 6 wk later, received local injections of sFRP2 or saline. Anal canal pressure was recorded before injury, immediately after myotomy, 6 wk postinjury, and every 2 wk for 6 wk following treatment with sFRP2. Myotomy significantly reduced anal canal pressure and induced fibrosis in the EAS muscle at 6 wk. sFRP2 treatment restored anal canal pressure to near preinjury levels within 2 wk after sFRP2 injection, which remained elevated 6 wk posttreatment, whereas saline-treated rabbits maintained low pressure. In the sFRP2 compared with saline-treated animals, (
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