Evidence map›Paper›PMID 42771697›Full record

ArticleRedox report : communications in free radical research2026

γ-Glutamylcysteine alleviates hypertension and vascular remodeling in SHR by suppressing oxidative stress through Keap1 S-glutathionylation.

Jianzhen Lei, Yueru Kong, Chao Ye, Chuanyue Zhang, Yi Shen, Xin Wu, Qiuyue Wu, Ying Han, Min Chen, Yueqi Song and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianzhen LeiInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Yueru KongInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Chao YeDepartment of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Chuanyue ZhangInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Yi ShenInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Xin WuInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Qiuyue WuInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Ying HanInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Min ChenInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.
Yueqi SongInstitute of Laboratory Medicine, Jinling Hospital, Nanjing Medical University, Nanjing.
Qing YanDepartment of Hematology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Fen ZhengThe Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China.
Xinyi XiaInstitute of Laboratory Medicine, Jinling Hospital, Affiliated Hospital of Medical School, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPathological arterial remodeling heavily depends on the aberrant proliferation and migration of vascular smooth muscle cells (VSMCs). This study explores how

methodsSpontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats received intraperitoneal injections of

resultsDISCUSSION:

Indexed as

DipeptidesHypertensionKelch-Like ECH-Associated Protein 1Oxidative StressVascular RemodelingAnimalsBlood PressureCell MovementCell ProliferationGlutathioneMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNF-E2-Related Factor 2RatsRats, Inbred SHRDipeptidesgamma-glutamylcysteineGlutathioneKEAP1 protein, ratKelch-Like ECH-Associated Protein 1Nfe2l2 protein, ratNF-E2-Related Factor 2hypertensionNrf2/Keap1oxidative stressphenotypic switchingS-glutathionylationvascular remodelingvascular smooth muscle cellsγ-Glutamylcysteine

Identifiers

PMID42771697
PMCPMC13600300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.