Evidence map›Paper›PMID 42771512›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Structural and functional divergence of cancer hotspot mutations in CREBBP.

Wenchao Zhang, Haopeng Yang, Ariel Mechaly, Zhongyang Li, Guiling Cui, Leslie Regad, Romain Duval, Julien Dairou, Ahmed Haouz, Michael R Green and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural and functional divergence of cancer hotspot mutations in CREBBP.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenchao Zhang *Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0002-6815-7173
Haopeng Yang *Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0002-3870-2679
Ariel MechalyInstitut Pasteur, Université Paris Cité, CNRS UMR 3528, Plate-forme de Cristallographie-C2RT, Paris F-75015, France.ORCID 0000-0002-5305-7495
Zhongyang LiUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris F-75013, France.
Guiling CuiUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris F-75013, France.
Leslie RegadUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris F-75013, France.ORCID 0000-0002-9292-5283
Romain DuvalUniversité Paris Cité and Université des Antilles, INSERM, UMRS 1134, Paris F-75015, France.ORCID 0000-0002-5785-0685
Julien DairouUniversité Paris Cité, CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Paris F-75006, France.
Ahmed HaouzInstitut Pasteur, Université Paris Cité, CNRS UMR 3528, Plate-forme de Cristallographie-C2RT, Paris F-75015, France.ORCID 0000-0003-1196-1635
Michael R GreenDepartment of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0001-6309-9472
Fernando Rodrigues LimaUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris F-75013, France.ORCID 0000-0002-1081-4767

Funding

Identifying/Targeting Mechanisms of Lymphomagenesis Driven by CREBBP InactivationR01CA201380 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Michael Richard Green · 2016 to 2026
$3.5M
HHS | NIH | National Cancer Institute (NCI) R01CA201380
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CREB-Binding ProteinMutationNeoplasmsAcetylationAcetyl Coenzyme AArginineCatalytic DomainHistonesHumansModels, MolecularProtein BindingAcetyl Coenzyme AArginineCREB-Binding ProteinCREBBP protein, humanHistonescancercrystal structurelymphomalysine acetyltransferasemutation

Identifiers

PMID42771512
PMCPMC13624666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.