Evidence map›Paper›PMID 42771298›Full record

ArticleEJNMMI research2026

Correlation of apparent diffusion coefficient, FAP expression in IHC and [

Madelaine Hettler, Franka Menge, Johannes Ludwig, Dominik Nörenberg, Stefan O Schönberg, Anna Hinterberger, Björn Wängler, Carmen Wängler, Henning Rudolf, Güllü Davarci and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Madelaine HettlerDepartment of Surgery, Sarcoma Unit, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. madelainehenny.hettler@umm.de.ORCID http://orcid.org/0000-0001-9728-2494
Franka MengeDepartment of Surgery, Sarcoma Unit, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Johannes LudwigDepartment of Radiology and Nuclear Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Dominik NörenbergDepartment of Radiology and Nuclear Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Stefan O SchönbergDepartment of Radiology and Nuclear Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Anna HinterbergerDKFZ Hector Cancer Institute at the University Medical Center Mannheim, Heidelberg, Germany.
Björn WänglerMedical Faculty Mannheim, Clinic of Radiology and Nuclear Medicine, Molecular Imaging and Radiochemistry, Heidelberg University, Mannheim, Germany.
Carmen WänglerMedical Faculty Mannheim, Heidelberg University, Research Campus M²OLIE, Mannheim, Germany.
Henning RudolfMedical Faculty Mannheim, Clinic of Radiology and Nuclear Medicine, Molecular Imaging and Radiochemistry, Heidelberg University, Mannheim, Germany.
Güllü DavarciMedical Faculty Mannheim, Clinic of Radiology and Nuclear Medicine, Molecular Imaging and Radiochemistry, Heidelberg University, Mannheim, Germany.
Patrick CieslikMedical Faculty Mannheim, Clinic of Radiology and Nuclear Medicine, Molecular Imaging and Radiochemistry, Heidelberg University, Mannheim, Germany.
Cristina L CotareloInstitute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Melissa HarbrückerDepartment of Surgery, Sarcoma Unit, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Christoph ReißfelderDKFZ Hector Cancer Institute at the University Medical Center Mannheim, Heidelberg, Germany.
Jens JakobDepartment of Surgery, Sarcoma Unit, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Wolfgang G KunzDepartment of Radiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Freba GraweDepartment of Radiology and Nuclear Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibroblast activation protein inhibitor (FAPI)-targeted positron emission tomography (PET) has emerged as a promising imaging approach in soft tissue sarcomas (STS), whereas magnetic resonance imaging (MRI) remains the diagnostic standard. We evaluated integrated [

resultsThirteen [

conclusionIn this exploratory pilot study, [68Ga]Ga-FAPI-46 PET/MRI provided complementary functional information in high-grade STS. Although no correlation with grading was observed either using SUVmax or ADC, a significant inverse correlation between ADCmean and SUVmax was identified within this cohort. Preliminary observations regarding treatment monitoring suggested that early changes in tracer uptake and ADC may reflect treatment-related changes, however, these findings were derived from a small pilot cohort. Larger prospective studies are required to validate these observations and to further define the potential role of [68Ga]Ga-FAPI-46 PET/MRI in treatment monitoring and response assessment.

Indexed as

[68Ga]Ga‑FAPI‑46 PET/MRIFunctional ImagingSoft Tissue SarcomaTreatment response

Identifiers

PMID42771298
PMCPMC13598007

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.