Evidence map›Paper›PMID 42771252›Full record

ArticlePediatric surgery international2026

The characteristics of liver nodules in biliary atresia native liver survivors.

John Yeh Joon Park, Patrick Ho Yu Chung, Fanny Yeung, Kenneth Kak Yuen Wong

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

John Yeh Joon ParkDivision of Paediatric Surgery, Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong.ORCID http://orcid.org/0009-0007-4489-9387
Patrick Ho Yu ChungDivision of Paediatric Surgery, Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong. chungphy@hku.hk.ORCID http://orcid.org/0000-0003-2382-5681
Fanny YeungDivision of Paediatric Surgery, Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong.ORCID http://orcid.org/0000-0002-6403-6374
Kenneth Kak Yuen WongDivision of Paediatric Surgery, Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong.ORCID http://orcid.org/0000-0001-7371-503X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo delineate features of hepatic nodules in native liver survivors (NLS) of biliary atresia (BA) post-Kasai portoenterostomy (KPE) and determine the surveillance utility of tumour markers and imaging studies.

methodsThis retrospective study conducted in a tertiary referral centre evaluated post-KPE patients who developed liver nodules following operations performed between 1979-2020. These included NLS at time of writing and liver transplant (LT) recipients with evidence of nodules before LT. Demographic, biochemistry, tumour markers, imaging, and histopathological data were collected. Dysplastic and non-dysplastic nodules were compared using Mann-Whitney U and Fisher's exact test.

resultsAmong 163 BA patients, of 96 NLS, 17 developed nodules; of 67 post-LT patients, 6 developed nodules before LT. Together, 23 post-KPE patients with nodules were analyzed: 4 dysplastic (one progressed into early hepatocellular carcinoma) and 19 benign lesions. Dysplastic nodules appeared earlier (8.2 vs. 21.2 years, p=0.286) and were larger (11.6 vs. 2.2cm

conclusionIn BA NLS, one-quarter develop hepatic nodules over time; malignant changes are rare, but can occur. Additionally, contrast-enhanced CT surveillance may be useful for larger, or earlier-detected hepatic nodules.

Indexed as

Biliary AtresiaLiver NeoplasmsPortoenterostomy, HepaticPostoperative ComplicationsChildChild, PreschoolFemaleHumansInfantLiver TransplantationMaleRetrospective StudiesSurvivorsTomography, X-Ray ComputedBiliary atresiaKasai portoenterostomyLiver nodulePaediatric

Identifiers

PMID42771252
PMCPMC13597636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.