Liver Structure after Administration of Autophagy-Modifying Drugs in Mice with Experimental Skin Melanoma.

E A Telpukhovskaia, M A Karpov, N P Bgatova, V V Klimontov, Iu S Taskaeva

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E A TelpukhovskaiaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. katetelpukhovsky@gmail.com.

M A KarpovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

N P BgatovaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

V V KlimontovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Iu S TaskaevaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphological changes in the liver were evaluated in mice with implanted B16 skin melanoma after chloroquine and lithium carbonate administration. In mice treated with lithium carbonate, lower volume and numerical densities of degenerative and necrotic lesions were revealed. In mice treated with chloroquine, the number of degenerative and necrotic changes did not differ from that in the pathological control group (mice with tumors). The numerical density of binucleated hepatocytes was higher in the chloroquine-treated group. In tumor-bearing mice treated with either chloroquine or lithium, collagen deposits were detected in the portal triads. The administration of autophagy inducer lithium carbonate promoted intracellular regeneration of hepatocytes. Chloroquine, a well-known autophagy blocker, did not affect the development of hepatocyte degeneration and necrosis, but stimulated the cell regeneration. Collagen deposits were found in all studied groups.

Indexed as

chloroquinelithium carbonatelivermouseskin melanoma

Identifiers

PMID42771241

DOI10.1007/978-1-59745-157-4_4

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.