Evidence map›Paper›PMID 42771238›Full record

ArticleBulletin of experimental biology and medicine2026

Leptin Associates with Circadian Light Hygiene and REV-ERBα in Arctic Residents.

D G Gubin, S N Kolomeychuk, M F Borisenkov, I M Petrov, A A Markov, Yu A Petrova, K A Voronin, M S Mezhakova, Y V Boldyreva, A U Shigabaeva

Abstract read
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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

D G GubinTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia. dgubin@mail.ru.
S N KolomeychukTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
M F BorisenkovInstitute of Physiology, Komi Science Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
I M PetrovTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
A A MarkovTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
Yu A PetrovaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
K A VoroninTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
M S MezhakovaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
Y V BoldyrevaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
A U ShigabaevaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leptin regulates metabolism and is modulated by circadian rhythms and light exposure, which is of fundamental importance for Arctic residents living under conditions of extreme photoperiods. This longitudinal study aimed to investigate the association between morning leptin, seasonal circadian light hygiene, and NR1D1 expression in 64 Arctic residents (aged 18‑54 years; 88.7% women) using 7‑day actigraphy, morning leptin and NR1D1 expression. Better circadian light hygiene, measured as normalized blue light exposure amplitude (NA BLE) was associated with lower morning leptin (β = -0.263; p < 0.001), also after adjusting for photoperiod. This association remained significant after controlling for sex, age, and ethnicity (β = -0.171). Later BLE light onset also predicted elevated leptin (β = 0.162; p = 0.031). In non-natives exclusively, reduced NR1D1 expression correlated with higher leptin (β = -0.276; p = 0.026).

Indexed as

Circadian RhythmLeptinNuclear Receptor Subfamily 1, Group D, Member 1ActigraphyAdolescentAdultArctic RegionsBlue LightFemaleHumansLongitudinal StudiesMaleMiddle AgedPhotoperiodSeasonsYoung AdultLeptinNR1D1 protein, humanNuclear Receptor Subfamily 1, Group D, Member 1actigraphyArcticleptinlightNR1D1 (REV-ERBα)

Identifiers

PMID42771238

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.