Evidence map›Paper›PMID 42771234›Full record

ArticleBulletin of experimental biology and medicine2026

DNA Damage in Placental and Fetal Cells in Rats with Perinatal Immune Activation.

A K Zhanataev, E A Anisina, K L Pligina, A S Solomina, A D Durnev

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A K ZhanataevFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia. zhanataev_ak@academpharm.ru.
E A AnisinaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
K L PliginaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
A S SolominaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
A D DurnevFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear and mitochondrial DNA damage in placental and fetal cells of rats was evaluated in a LPS-induced model of perinatal immune activation. Six hours after a single administration of LPS (0.2 mg/kg), an increase in nuclear DNA damage was observed in both placental and fetal cells. The most pronounced changes were detected in the fetal head region. After 24 h, damage to nuclear DNA was detected in placental cells and the trunk of the fetuses. High variability of this parameter was observed between the placental and fetal samples from the same animal and between different animals. No increase in nuclear DNA damage was revealed 3 h after LPS treatment. Mitochondrial DNA damage in the studied cells was detected after a 6-h exposure to LPS.

Indexed as

DNA DamageFetusPlacentaAnimalsCell NucleusDNA, MitochondrialFemaleLipopolysaccharidesPregnancyRatsRats, WistarDNA, MitochondrialLipopolysaccharidesDNA damagefetuslipopolysaccharideperinatal immune activationrats

Identifiers

PMID42771234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.