Evidence map›Paper›PMID 42771222›Full record

ArticleCVIR endovascular2026

Antioxidant premedication reduces mitochondrial and nuclear DNA damage repair in interventional physicians performing X-ray-guided angiography procedures: a pilot clinical intervention study.

Kieran Murphy, Thomas Lindsay, Kongteng Tan, Sean Lau, Gavin Elias, Kieran Luke, Josh Nederveen, Donald Xhuti, Mahek Minhas, Benjamin Lok and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CVIR endovascular, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kieran MurphyDepartment of Medical Imaging, Toronto Western Hospital, University Health Network, 399 Bathurst St., 3rd Fl., Toronto, ON, M5T2S8, Canada.
Thomas LindsayDivision Vascular Surgery, Toronto General Hospital, University Health Network, 200 Elizabeth St., 6EN-228, Toronto, ON, M5G2C4, Canada.
Kongteng TanJoint Department of Medical Imaging, University Health Network, 700 University Avenue, 2nd Fl., Toronto, ON, M5G1X6, Canada.
Sean LauJoint Department of Medical Imaging, University Health Network, 700 University Avenue, 2nd Fl., Toronto, ON, M5G1X6, Canada.
Gavin EliasJoint Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Fl., Toronto, ON, M5T1W7, Canada.
Kieran LukeJoint Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Fl., Toronto, ON, M5T1W7, Canada.
Josh NederveenDepartment of Kinesiology, Faculty of Science, McMaster University, 1280 Main St. W., Hamilton, ON, L8S4K1, Canada.
Donald XhutiFaculty Health Sciences, Medical Sciences Graduate Program, McMaster University, 1200 Main St. W., Hamilton, ON, L8N3Z5, Canada.
Mahek MinhasFaculty Health Sciences, Medical Sciences Graduate Program, McMaster University, 1200 Main St. W., Hamilton, ON, L8N3Z5, Canada.
Benjamin LokRadiation Medicine Program, Princess Margaret Cancer Center, 610 University Avenue, Toronto, ON, M5G2M9, Canada.
Shusen ZhuRadiation Medicine Program, Princess Margaret Cancer Center, 610 University Avenue, Toronto, ON, M5G2M9, Canada.
Gaylene PronInstitute Health Policy Management and Evaluation, University of Toronto, Health Sciences Bldg., 155 College St., Toronto, ON, M5T3M7, Canada. g.pron@utoronto.ca.ORCID http://orcid.org/0000-0001-6440-9655
Mark TarnopolskyDepartment of Pediatrics, McMaster Children's Hospital, 1200 Main St. W., Hamilton, ON, L8N3Z5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo examine effects of naturally occurring antioxidants on DNA damage repair acute responses of ionizing radiation sustained by interventional physicians during angiography.

methodsThe study cohort included 20 interventional physicians (19 males, 1 female; mean age: 45.4 ± 13.2 years) performing angiography fluoroscopically guided procedures. Participants were allocated to a treatment group receiving oral antioxidants (N = 10/group) before starting day cases or to an untreated control group performing procedures without antioxidants (N = 10/group). mRNA biomarkers of nuclear and mitochondrial DNA injury repair response in peripheral blood lymphocytes were assessed before and after workday.

resultsBaseline DNA repair biomarkers and procedural fluoroscopic exposures were similar between the study groups. Individual pre-post changes in MRNA levels were not significant for any biomarkers in the antioxidant-treated group but were significantly increased in the untreated control group for P53 (P = 0.006), NF-κB (P = 0.002), and COX4i1 (P = 0.004). Between-group differences in post-exposure gene expression were significantly (P = 0.024) higher with P53 being 78% higher in the untreated versus the treated group and COX4i1 levels also significantly (P = 0.028) higher by 46% in the untreated group. Absolute change in the STAT3 mRNA level was higher by 54% in the untreated group but between-group difference was not significant (P = 0.066). There was a lower burden of NF-κB mRNA levels of inflammation in the treatment than the untreated group (18 ± 8% versus 60 ± 15%) with significant between-group difference (P = 0.020).

conclusionsSignificant elevations in peripheral blood lymphocytes of mRNA biomarkers of nuclear and mitochondrial DNA injury repair response occurred in untreated interventional physicians exposed to ionizing radiation during fluoroscopically guided interventions. In physicians pretreated with a novel antioxidant formulation, biomarkers of DNA repair responses were significantly attenuated suggesting a decreased acute IR-induced oxidative stress-mediated DNA damage response.

Indexed as

AntioxidantsDNA damage responseIonizing radiationMitochondrial DNANuclear DNAOxidative stress

Identifiers

PMID42771222
PMCPMC13597979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.