ArticleClinical rheumatology2026
Clinical features and prognostic factors of hospitalized patients with acute exacerbation of interstitial lung disease secondary to dermatomyositis/polymyositis.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
INTRODUCTION/
objectivesAcute exacerbation of interstitial lung disease secondary to dermatomyositis or polymyositis (DM/PM-AEILD) is an intractable, life-threatening disease with unsatisfactory therapeutic efficacy, particularly in patients positive for anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody (Ab). Identifying prognostic risk factors for DM/PM-AEILD might help clinicians to stratify high-risk patients at an early stage and deliver targeted standardized treatment.
methodsWe retrospectively collected clinical data of 35 hospitalized patients diagnosed with DM/PM-AEILD, including 18 patients with anti-MDA5-Ab
resultsThe cohort consisted of 21 females and 14 males; the mean age was 62.11 ± 10.78 years. The overall in-hospital mortality of DM/PM-AEILD reached 42.9%, and the mortality climbed to 66.7% among anti-MDA5 Ab
conclusionsPatients hospitalized with DM/PM-AEILD suffer high in-hospital mortality, which is further elevated in anti-MDA5 Ab
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