ArticleActa neurologica Belgica2026
Differential improvement in patient-reported outcomes measurement information system (PROMIS) domains after ventriculoperitoneal shunting (VPS) for idiopathic normal pressure hydrocephalus (iNPH).
Article in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatient-Reported Outcomes Measurement Information System (PROMIS) is a patient-reported outcome tool to overview various functional domains of health. We describe longitudinal changes in various PROMIS domains after ventriculoperitoneal shunting (VPS) for patients with idiopathic normal pressure hydrocephalus (iNPH).
methodsPatients with "probable" iNPH who underwent VPS from December 2017 to January 2025 and had completed pre- and post-operative PROMIS computerized adaptive testing (CAT) were retrospectively reviewed. Domains assessed included anxiety, depression, fatigue, sleep disturbance, pain interference, social ability, and physical function. Generalized additive mixed models (GAMM) were utilized to assess longitudinal changes in each domain while controlling for variable follow-up time and patient-specific repeated measures. Principal component analysis (PCA) was performed to identify patterns of change.
resultsA total of 173 patients with 461 PROMIS assessments (median 3 per patient) were included with median follow-up time of 10.3 months (IQR 3.3-13.1). Patients undergoing VPS for iNPH had statistically worse pre-operative PROMIS measures (Benjamini-Hochberg adjusted Wilcoxon p<0.05) in all domains except sleep disturbance. Overall, statistically significant and temporally durable T-score improvements after VPS were identified in fatigue, physical function, and social ability. Differential patterns of post-VPS PROMIS changes disclosed three distinct patient clusters with differing baseline PROMIS functions and comorbidity burdens.
conclusionsApproximately half of iNPH patients report significant improvement in various PROMIS domains longitudinally after VPS. Physical function demonstrated both the greatest magnitude of baseline dysfunction and improvement after VPS. With additional notable improvements in fatigue, and social ability, VPS may improve multiple functional healthcare-related quality of life domains.
Indexed as
Identifiers
42771100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.