Evidence map›Paper›PMID 42770958›Full record

ArticleJournal of human immunity2026

A fatal case of Aspergillus endocarditis in a pediatric patient with STING-associated vasculopathy.

Ambre Dethier, Fanny Bajolle, Paul Bastard, Laureline Berteloot, Romain Lévy, Filippo Consonni, Quentin Deletang, Eric Dannaoui, Olivier Raisky, Philippe Drabent and 6 more

Abstract read
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ambre DethierUniversité Paris Cité , Paris, France.ORCID 0009-0001-3534-9021
Fanny BajolleM3C-Paediatric Cardiology Center, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris , Paris, France.ORCID 0000-0002-1106-0987
Paul BastardUniversité Paris Cité , Paris, France.ORCID 0000-0002-5926-8437
Laureline BertelootDepartment of Pediatric Radiology, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0000-0001-9681-3142
Romain LévyUniversité Paris Cité , Paris, France.ORCID 0000-0002-6393-0198
Filippo ConsonniPediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0000-0002-6879-8982
Quentin DeletangPediatric Hematology-Immunology and Rheumatology Unit, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0009-0001-3410-6060
Eric DannaouiUniversité Paris Cité , Paris, France.ORCID 0000-0002-2817-3830
Olivier RaiskyDepartment of Pediatric Cardiac Surgery, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0009-0008-3992-029X
Philippe DrabentDepartment of Pathology, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0000-0003-0273-0050
Jacinta BustamanteUniversité Paris Cité , Paris, France.ORCID 0000-0002-3439-2482
Fréderic Rieux-LaucatImmunogenetic of Autoimmune Diseases, INSERM UMR 1163, Institut Imagine , Paris, France.ORCID 0000-0001-7858-7866
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Imagine Institute, Paris, France.ORCID 0000-0003-2603-0323
Fanny LanternierUniversité Paris Cité , Paris, France.ORCID 0000-0003-3800-4683
Marie-Louise FrémondUniversité Paris Cité , Paris, France.ORCID 0000-0002-2798-9141
Bénédicte NevenUniversité Paris Cité , Paris, France.ORCID 0000-0001-8941-0935

Funding

Agence Nationale de la Recherche ANR-10-IAHU-01Agence Nationale de la Recherche ANR-14-CE14-0026Agence Nationale de la Recherche ANR-18-CE17-001Agence Nationale de la Recherche ANR-18-RHUS-0010Centre National de Référence des Mycoses Invasives et AntifongiquesFondation Bettencourt-SchuellerFondation pour la Recherche Médicale EQU202103012670Fondation pour la Recherche Médicale EQU202503020056French Foundation for Medical Research EA20170638020Imagine InstituteInstitut National de la Santé et de la Recherche Médicale
6 · The paper itself

Abstract

SAVI is a rare STING1 gain-of-function disorder causing systemic inflammation, vasculopathy, and interstitial lung disease. JAK inhibitors are first-line therapy. We report a SAVI patient on prolonged JAK inhibitors who developed opportunistic infections, including fatal Aspergillus endocarditis, underscoring therapeutic challenges.

Identifiers

PMID42770958
PMCPMC13596074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.