Evidence map›Paper›PMID 42770912›Full record

ArticleActa dermato-venereologica2026

Physical Activity and Risk of Autoimmune Bullous Skin Diseases: A Prospective Cohort Study.

Shuai Ju, Guowei Zhou, Changmin Liu, Fangfang Li, Qingyu Hong, Wanyao Liu, Hong Liu, Jia Guo

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In one paragraph

Article in Acta dermato-venereologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuai JuDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China.
Guowei ZhouDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China.
Changmin LiuSchool of Foreign Languages and Literature, Shandong University, Jinan 250100, China.
Fangfang LiDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China.
Qingyu HongDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China.
Wanyao LiuDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China.
Hong LiuDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China. hongliu1014@csu.edu.cn.ORCID 0000-0002-2083-0103
Jia GuoDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan 410008, China. jiaguo1128@csu.edu.cn.ORCID 0009-0002-4903-508X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity has been linked to immunee regulation in several autoimmune diseases, but its association with autoimmune bullous skin diseases (AIBD), mainly pemphigus and pemphigoid, has not been adequately evaluated. We examined the association between regular physical activity and incident AIBD in 476,057 UK Biobank participants. Multivariable-adjusted Cox models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AIBD risk according to habitual physical activity. We also assessed joint associations with polygenic risk and performed mediation analysis. During a median follow-up of 15.21 years, 272 incident AIBD cases were documented, including 61 pemphigus and 211 pemphigoid cases. Physically active participants had a 31% lower risk of AIBD than inactive participants (adjusted HR 0.69, 95% CI 0.54-0.88). Similar associations were observed for pemphigus (HR 0.53) and pemphigoid (HR 0.72). Individuals with high genetic risk who were physically inactive had a higher risk than physically active individuals with low genetic risk (HR 2.12, 95% CI 1.47-3.07). In an exploratory mediation analysis, BMI accounted for 8.86 % of the association. These findings suggest that regular physical activity is associated with a lower risk of AIBD after adjustment for genetic susceptibility and other risk factors.

Indexed as

Autoimmune DiseasesExercisePemphigoid, BullousPemphigusSkin Diseases, VesiculobullousAdultAgedFemaleGenetic Predisposition to DiseaseHumansIncidenceMaleMiddle AgedProspective StudiesProtective FactorsRisk Assessment

Identifiers

PMID42770912
PMCPMC13595829

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.