Evidence map›Paper›PMID 42770873›Full record

ArticleTransboundary and emerging diseases2026

Andrographolide Inhibits Rabies Virus Replication.

Yue Zhang, Lanxi Zheng, Yueze Wang, Songze Zhao, Hongling He, Shile Huang, Jun Luo, Xiaofeng Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yue ZhangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.ORCID https://orcid.org/0009-0007-5736-4787
Lanxi ZhengCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.ORCID https://orcid.org/0009-0001-9964-9250
Yueze WangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.
Songze ZhaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.
Hongling HeCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.
Shile HuangDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport 71130-3932, Louisiana, USA, lsu.edu.ORCID https://orcid.org/0000-0002-3239-1072
Jun LuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.ORCID https://orcid.org/0000-0003-4422-9619
Xiaofeng GuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China, scau.edu.cn.ORCID https://orcid.org/0000-0003-2896-3629

Funding

National Key Research and Development Program of China 2022YFD1800100National Natural Science Foundation of China 32473115Specific University Discipline Construction Project 2023B10564003
6 · The paper itself

Abstract

Rabies is a fatal zoonotic disease caused by infection with the rabies virus (RABV). Anti-RABV serum or antibody is a unique treatment for patients infected by RABV. However, the mortality is almost 100% in the underdeveloped regions due to the high price and the high cost of transportation and preservation of anti-RABV serum or antibody. Therefore, it is urgently needed to develop novel therapies that can effectively fight against RABV infection. Andrographolide (Andro) is a labdane diterpenoid isolated from Andrographis paniculate, which has been used to treat bacterial and viral infections for decades. In this study, we found that Andro dose-dependently inhibited RABV replication in host cells, with a half-maximal effective concentration (EC

Indexed as

Antiviral AgentsDiterpenesRabiesRabies virusVirus ReplicationAnimalsMiceandrographolideAntiviral AgentsDiterpenesandrographolideantiviralrabies virusreplicationsurvival rates

Identifiers

PMID42770873
PMCPMC13596000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.