Evidence map›Paper›PMID 42770840›Full record

ArticleeLife2026

Wound-induced syncytia outpace mononucleate neighbors during

James S White, Junmin Hua, Jasmine J Su, Kaden J Tro, Elizabeth M Ruark, M Shane Hutson, Andrea Page-McCaw

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Epithelial cell fusion is required for tissue repair following UV-A irradiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

James S WhiteDepartment Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, United States.
Junmin HuaDepartment Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, United States.ORCID https://orcid.org/0009-0001-2080-2452
Jasmine J SuDepartment Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, United States.
Kaden J TroDepartment Physics and Astronomy Vanderbilt University Nashville, Nashville, United States.ORCID https://orcid.org/0009-0006-8655-518X
Elizabeth M RuarkDepartment Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, United States.
M Shane HutsonDepartment Biological Sciences, Vanderbilt University, Nashville, United States.ORCID https://orcid.org/0000-0002-1647-6092
Andrea Page-McCawDepartment Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, United States.ORCID https://orcid.org/0000-0003-3193-5362

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Training Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4M
Cellular Integration of Information in the Detection and Response to Epithelial DamageR01GM130130 · NIGMS · VANDERBILT UNIVERSITY · PI HUTSON, M. SHANE, PAGE-MCCAW, ANDREA · 2018 to 2025
$2.9M
American Heart Association 10.58275/aha.25pre1374646.pc.gr.227182NICHD NIH HHS T32 HD007502NIGMS NIH HHS R01 GM130130NIGMS NIH HHS R01GM130130NIH HHS P40 OD018537
6 · The paper itself

Abstract

In response to injury, cells proliferate, migrate, and invade to replace missing cells and close wounds. However, the role of other wound-induced cell behaviors is not understood, including the formation of syncytia (multinucleated cells). Here, we use in vivo live imaging to analyze wound-induced syncytia in mitotically competent

Indexed as

DrosophilaDrosophila melanogasterGiant CellsWound HealingAnimalsCell FusionDrosophila ProteinsEpithelial CellsPupaDrosophila Proteinscell biologycell fusionD. melanogasterpolyploidytissue repairvertex model

Identifiers

PMID42770840
PMCPMC13597085

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.