ArticleInternational journal of rheumatic diseases2026
DN4-Positive Neuropathic Pain Features in End-Stage Knee Osteoarthritis Awaiting Arthroplasty: Prevalence and Relationship With Function and Quality-of-Life.
Article in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesThis cross-sectional study investigated the occurrence of neuropathic pain features (NP) in individuals with end-stage knee osteoarthritis (KOA) referred to total knee arthroplasty (TKA) and explored its association with functional and quality-of-life outcomes.
methodsIn 902 patients, NP was screened using the Douleur Neuropathique 4 (scores ≥ 4). Distribution of NP features (positive/negative) regarding sex were assessed with z-test for proportions. The influence of NP features on the outcomes (visual analog scale for pain, WOMAC, SF-36) were tested with the Mann-Whitney U, followed by a multivariate logistic regression model to identify independent predictors of NP features, using 5% as statistical threshold.
resultsThe cohort was 72.6% female, with a mean ± SD age of 70 ± 8 years. NP-positive features prevalence was 28.6% (95% CI of 25.7%-31.6%), which was significantly higher in females (31.5%) than males (21.1%; p < 0.001). Patients with NP-positive features reported worse scores across all measured domains: higher pain intensity (VAS; p < 0.001), worse knee-related symptoms/function (WOMAC pain, function, and total scores; all p < 0.001), and lower quality-of-life in specific SF-36 domains (general health, vitality, role-emotional, mental health; all p < 0.01). The multivariate model confirmed that higher WOMAC total score and specific SF-36 scores were independently associated with NP-positive features.
conclusionsNP features are prevalent in approximately one-third of the patients with end-stage KOA awaiting arthroplasty, particularly among females. Its presence is independently associated with poorer joint-related function and reduced quality-of-life, suggesting the potential value of NP features assessment and management into pre- and postsurgical care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.