Evidence map›Paper›PMID 42770556›Full record

ArticleeLife2026

PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development.

Julia Raulino Lima, Nicha Ungvijanpunya, Qing Chen, Hoang Quoc Hai Pham, Tal Rosen, Greg Park, Mohammadreza Vantankhah, Steven Yen, Yang Chai, Amy E Merrill and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Julia Raulino Lima *Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0002-6824-4904
Nicha Ungvijanpunya *Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Qing Chen *Department of Physics, The George Washington University, Washington, DC, United States.
Hoang Quoc Hai PhamDepartment of Cancer Genetics and Epigenetics, City of Hope, Duarte, United States.
Tal RosenCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Greg ParkCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Mohammadreza VantankhahCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Steven YenCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Yang ChaiCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0003-2477-7247
Amy E MerrillCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0002-3660-1575
Zhaoyang LiuCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Jian-Fu ChenCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Yanzhong YangDepartment of Cancer Genetics and Epigenetics, City of Hope, Duarte, United States.
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC, United States.ORCID https://orcid.org/0000-0001-5521-9091
Jian XuCenter for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0002-8162-889X

Funding

CLINICAL EFFECTIVENESS OF LATE MAXILLARY PROTRACTION FOR CLEFT LIP AND PALATEU01DE022937 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YEN, STEPHEN L-K · 2013 to 2017
$3.4M
Molecular Regulatory Mechanism of a Cartilage-Enriched GPCR in Joint MaintenanceR01AR083966 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Zhaoyang Liu · 2025 to 2026
$832k
Anandamahidol foundation scholarshipNIAMS NIH HHS R01 AR083966NIAMS NIH HHS R01AR083966NIDCR NIH HHS R01DE028943NIDCR NIH HHS T90NIDCR NIH HHS U01 DE022937NIDCR NIH HHS U01DE022937
6 · The paper itself

Abstract

Spliceosomopathies, which are a group of disorders caused by defects in the splicing machinery, frequently affect the craniofacial skeleton and limb, but the molecular mechanism underlying this tissue-specific sensitivity remains unclear. Splicing factors and small nuclear ribonucleoproteins (snRNPs) are core components of splicing machinery, and splicing factors are further controlled by post-translational modifications, among which arginine methylation is one of the most prevalent. We determined the splicing mechanisms in the cranial neural crest cells (CNCCs), a multipotent developmental population that gives rise to the majority of the craniofacial skeleton, and focused on an upstream regulator of splicing proteins, protein arginine methyltransferase 1 (PRMT1). PRMT1 is the highest expressing arginine methyltransferase in CNCCs, and its role in craniofacial development is evident from our earlier investigation, where CNCC-specific

Indexed as

Gene Expression Regulation, DevelopmentalIntronsProtein-Arginine N-MethyltransferasesRepressor ProteinsRNA Splicing FactorsAnimalsMiceNeural CrestPrmt1 protein, mouseProtein-Arginine N-MethyltransferasesRepressor ProteinsRNA Splicing Factorsarginine methylationcraniofacial biologydevelopmental biologygeneticsgenomicsintron retentionmouseneural crestSFPQsplicing

Identifiers

PMID42770556
PMCPMC13597084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.