Evidence map›Paper›PMID 42770487›Full record

Trial reportPsycho-oncology2026

Improvements in Health-Related Quality of Life After Financial Navigation Among Cancer Survivors.

Austin R Waters, Bridgette Thom, Allison M Deal, Camille R Murray, Kevin Pignone, Michelle L Manning, Mindy Gellin, Neda R Padilla, Lisa P Spees, Arrianna Marie Planey and 3 more

Registry-linked trialAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04931251 (Addressing Cancer-Related Financial Toxicity in Rural North Carolina Oncology Care Settings), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04931251 nacompletednot on this map

Addressing Cancer-Related Financial Toxicity in Rural North Carolina Oncology Care Settings

TypeinterventionalSponsorUNC Lineberger Comprehensive Cancer CenterRan2021 to 2025Enrolled258ConditionsNeoplasms, CarcinomaArmsFinancial Navigation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Austin R WatersDepartment of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-9947-8535
Bridgette ThomLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-6239-1666
Allison M DealLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0003-3526-3938
Camille R MurrayDepartment of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-2481-4485
Kevin PignoneDepartment of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michelle L ManningLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0009-0009-0894-7956
Mindy GellinLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Neda R PadillaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lisa P SpeesLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-5680-9330
Arrianna Marie PlaneyDepartment of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0003-4739-090X
Katherine E Reeder-HayesLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-6903-0177
Donald L RosensteinLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-8611-8012
Stephanie B WheelerDepartment of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Program Project – Improving Provider Announcement Communication Training (IMPACT)P01CA250989 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILKEY, MELISSA B · 2021 to 2025
$11.7M
Training in Oncology Population Sciences (TOPS)T32CA092203 · NCI · DANA-FARBER CANCER INST · PI Nancy L Keating, JENNIFER W MACK · 2018 to 2026
$3.7M
Cancer Care Quality Training ProgramT32CA116339 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ETHAN M. BASCH, Stephanie Brooke Wheeler · 2018 to 2026
$3.0M
Examining the Relationship Between Spatial Accessibility to Care, FT, and HRQoL Among Rural Cancer SurvivorsR01CA240092 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSENSTEIN, DONALD L, WHEELER, STEPHANIE BROOKE · 2019 to 2022
$2.2M
Improving Affordability in Cancer Care through Economic Screening and Support (I-ACCESS)K01CA304478 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bridgette H Thom · 2025 to 2026
$395k
NCI NIH HHS 1-R01-CA240092-02NCI NIH HHS K01CA250989NCI NIH HHS K01 CA304478NCI NIH HHS K01CA304478NCI NIH HHS P01 CA250989NCI NIH HHS P30 CA016086NCI NIH HHS P30‑CA016086‑44‑S4NCI NIH HHS R01 CA240092NCI NIH HHS T32 CA092203NCI NIH HHS T32CA092203NCI NIH HHS T32 CA116339NCI NIH HHS T32CA116339
6 · The paper itself

Abstract

backgroundFinancial toxicity is associated with worse health outcomes among cancer survivors. It is unknown if financial navigation (FN) can meaningfully improve the health of survivors experiencing financial toxicity.

aimsThis analysis assesses changes in health-related quality of life (HRQoL) among cancer survivors receiving an FN intervention.

methodsA single-arm Type II Hybrid Implementation-Effectiveness clinical trial was conducted at eight clinical oncology sites in North Carolina. Cancer survivors within five years of diagnosis or living with advanced disease with a COmprehensive Score for financial Toxicity (COST-FACIT) score of < 23, and the ability to read and understand English were recruited to receive the Lessening the Impact of Financial Toxicity (LIFT) intervention, which included a comprehensive intake and at least one check-in with a trained navigator. Participants completed the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Physical and Mental Health, Anxiety, Depression, and Psychosocial Illness Impact-Positive measures.

resultsA total of N = 86 cancer survivors received the LIFT FN intervention and completed baseline and follow-up surveys. Receipt of LIFT FN was associated with statistically significant improvements in measures of global mental health (change: 1.72, 95% CI: 0.07, 3.38), depression (change: -2.07, 95% CI: -3.90, -0.25), and anxiety (change: -3.33, 95% CI: -5.42, -1.24). From baseline to follow-up, mean depression scores clinically improved from "mild" to "within normal limits," and mean anxiety scores clinically improved from "moderate" to "mild."

conclusionsOur findings demonstrate that receipt of FN decreased anxiety and depression and improved global mental health. Findings highlight the crucial role of FN in cancer care.

trial registrationNCT04931251.

Indexed as

Cancer SurvivorsFinancial StressNeoplasmsPatient NavigationQuality of LifeAdultAgedAnxietyDepressionFemaleHumansMaleMental HealthMiddle AgedNorth CarolinaPatient Reported Outcome Measures

Identifiers

PMID42770487
PMCPMC13595495

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.