Evidence map›Paper›PMID 42770280›Full record

ArticleeLife2026

Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity.

Florence Authier, Asad Jan, Islam Faress, Christian Stald Skoven, Iria Esperon-Abril, Shagana Tharmakulasingam Balasubramaniam, Kévin-Sébastien Coquelin, Jens R Nyengaard, Carsten Scavenius, Benedetta Attianese and 5 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Florence Authier *Section for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0965-9165
Asad Jan *Core Center for Molecular Morphology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Islam FaressSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Christian Stald SkovenCFIN, Aarhus Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0639-6718
Iria Esperon-AbrilSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Shagana Tharmakulasingam BalasubramaniamSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Kévin-Sébastien CoquelinSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Jens R NyengaardCore Center for Molecular Morphology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Carsten ScaveniusSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Benedetta AttianeseSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Oscar G Sevillano-QuispeSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Simon Fristed EskildsenCFIN, Aarhus Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-4242-9158
Jesper Skovhus ThomsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-9386-6679
Brian HansenCFIN, Aarhus Hospital, Aarhus, Denmark.
Daan M F van AaltenSection for Neurobiology and DANDRITE, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-1499-6908

Funding

Novo Nordisk Fonden NNF21OC0065969Villum Fonden 00054496Wellcome TrustWellcome Trust 10.35802/110061
6 · The paper itself

Abstract

Missense variants in the O-GlcNAc transferase (

Indexed as

AcetylglucosamineHyperkinesisIntellectual DisabilityMalformations of Cortical DevelopmentN-AcetylglucosaminyltransferasesAnimalsDisease Models, AnimalMiceAcetylglucosamineN-AcetylglucosaminyltransferasesO-GlcNAc transferaseOgt protein, mousebehaviourcortical dysplasiaintellectual disabilitymouseneurodevelopmentneuroscienceO-GlcNAcO-glycosylation

Identifiers

PMID42770280
PMCPMC13597087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.