Evidence map›Paper›PMID 42770181›Full record

ArticleJournal of microbiology and biotechnology2026

Exosomal circ-ZNF652 Mediates TGF-β1-Induced Epithelial-Mesenchymal Transition and Glycolytic Reprogramming to Promote Hepatocellular Carcinoma Progression.

Xianli Niu, Xiaomin Zhang, Guangxia Liang, Nina Wei, Haibo Peng, Xiangyang Li

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Article in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xianli NiuGuangdong Jiangmen College of Chinese Medicine, Jiangmen, Guangdong 529000, P. R. China.
Xiaomin ZhangGuangdong Jiangmen College of Chinese Medicine, Jiangmen, Guangdong 529000, P. R. China.
Guangxia LiangThe Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai, Guangdong 519100, P. R. China.
Nina WeiZhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong 519041, P. R. China.
Haibo PengZhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong 519041, P. R. China.
Xiangyang LiGuangdong Provincial People's Hospital Zhuhai Hospital (Jinwan Central Hospital of Zhuhai), Zhuhai, Guangdong 519000, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) progression involves epithelial-mesenchymal transition (EMT) and glycolytic reprogramming induced by TGF-β1. The role of exosomal circular RNAs in coordinating these processes remains unclear. This study aims to investigate whether exosomal circ-ZNF652 is associated with TGF-β1-induced mesenchymal marker induction and glycolysis in HCC and elucidate the underlying mechanism. Exosomes were isolated from SMMC-7721 cells and characterized by TEM, NTA, and CD63 western blot. RT-qPCR measured circ-ZNF652 expression. Cell viability, migration, cycle, and apoptosis were assessed by MTT, wound healing, and flow cytometry. EMT and glycolysis proteins were detected by western blot. Glucose uptake, lactate, and HK/LDHA activities were measured.

Indexed as

Carcinoma, HepatocellularEpithelial-Mesenchymal TransitionExosomesGlycolysisLiver NeoplasmsRNA, CircularTransforming Growth Factor beta1AnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor 1, alpha SubunitRNA, CircularTransforming Growth Factor beta1AKT/HIF-1α signaling pathwayCell proliferationEpithelial-mesenchymal transition (EMT)Exosomal circ-ZNF652Glycolytic reprogrammingHepatocellular carcinomaTransforming growth factor-β1 (TGF-β1)

Identifiers

PMID42770181

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.