Evidence map›Paper›PMID 42770164›Full record

ArticleNeurosurgery practice2026

Nasal Packing After Trans-Sphenoidal Surgery for Pituitary Tumor: A Pilot of a Randomized Controlled Trial.

Corliss Best, Fahad Alkherayf, Mohammed Saeed Alahmari, Ebraheem Alnofal, Mohammed Alqabasani, Abdullah Ahmed Asiri, Debora Hogan, Andrea Lasso, Shaun Kilty

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03677713 (Nasal Packing Following Endoscopic Endonasal Pituitary Resection), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03677713 nacompletednot on this map

Nasal Packing Following Endoscopic Endonasal Pituitary Resection

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2019 to 2024Enrolled60ConditionsPituitary TumorArmsNo nasal packing., Nasal Packing
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Corliss BestDepartment of Otolaryngology Head and Neck Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
Fahad AlkherayfOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Mohammed Saeed AlahmariDepartment of Otolaryngology Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.
Ebraheem AlnofalDepartment of Otolaryngology Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.
Mohammed AlqabasaniDepartment of Otolaryngology Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.
Abdullah Ahmed AsiriDepartment of Otolaryngology Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada.
Debora HoganOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Andrea LassoOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Shaun KiltyDepartment of Otolaryngology Head and Neck Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe goal of the study was to determine the feasibility of a larger trial to evaluate whether nasal packing after routine endoscopic endonasal resection of pituitary tumor negatively affects sinonasal quality of life (QOL) in the postoperative period and to evaluate the safety of not using nasal packing after routine endoscopic endonasal resection of pituitary tumor.

methodsWe conducted a parallel, nonblinded, randomized, pilot trial. A total of 60 patients were randomized to nasal packing (NP) (standard-of-care group) or no nasal packing (experimental group) after endoscopic endonasal trans-sphenoidal surgery (EETS) for the resection of a pituitary tumor. The primary outcome was sinonasal QOL measured using the Anterior Skull Base Nasal Inventory-12 questionnaire. Secondary outcomes included adverse events within 4 weeks of surgery, nasal pain, and health-related QOL using the EuroQol-5 dimension 5-level questionnaire tool.

resultsSeventy-nine patients were approached to participate, and 60 patients were randomized to NP (n = 31) or no nasal packing (n = 29) after EETS. There were no patient withdrawals after randomization; one patient was excluded from analysis due to complications unrelated to the study. There was no significant difference between groups in sinonasal QOL (

conclusionThe proposed trial was effective and acceptable to patients. A definite larger trial is feasible with some modifications. Preliminary results show that the use of nonabsorbable NP after EETS does not significantly affect sinonasal QOL.

trial registrationThe study was registered with the ClinicalTrials.gov database (NCT03677713).

Indexed as

Endoscopic endonasal trans-sphenoidal surgeryNasal packingPilot trialPituitary tumor surgeryPostoperative periodQuality of life

Identifiers

PMID42770164
PMCPMC13593028

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