Diagnostic value of serum NSE, and S-100β and inflammatory markers levels in epilepsy.

Zhaoxia Li, Li Su, Yi Lu, Yunqing Hu, Qian Yang

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Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Zhaoxia LiThe First Affiliated Hospital of Bengbu Medical University, Department of Neurology, Bengbu, China.

Li SuLixin County People's Hospital, Department of Laboratory Medicine, Bozhou, China.

Yi LuThe First Affiliated Hospital of Bengbu Medical University, Department of Neurology, Bengbu, China.

Yunqing HuLixin County People's Hospital, Department of Laboratory Medicine, Bozhou, China.

Qian YangHaikou Fourth People's Hospital, Department of Neurology, Haikou, China.

Funding

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6 · The paper itself

Abstract

Background: To sodium valproate lore the effects of sodium valproate on serum inflammatory factors and s-100β levels in patients with emergency secondary epilepsy(SE). Methods: This was a retrospective cohort of 120 patients with SE who received Sodium valproate compared with a group who received carbamazepine for different therapeutic drugs. The general data, interleukin (IL)-2, IL-8, tumour necrosis factor (TNF)-α, neuron-specific enolase (NSE), serum acid calcium-binding protein s-100β, total effective rate (TER), seizure onset condition, and adverse reactions (Ars) of the two groups were compared at baseline and at 3 months later. Results: There were no significant differences in age, gender, BMI, course of the disease, stroke type, or seizure type between the study groups (P> 0.05). The results showed that IL-2 of the Sodium valproate group (53.17± 4.95 μg/L) was lower versus Carbamazepine group (62.38± 4.83 μg/L) (P< 0.05). The IL-8 of the Sodium valproate group postoperatively (26.48± 2.73 μg/L) was lower versus the Carbamazepine group (33.54± 3.39 μg/L) (P< 0.05). Postoperatively, the TNF-α in Sodium valproate group (32.18± 4.26 μg/L) was lower versus the Carbamazepine group (41.03± 4.92 μg/L) (P< 0.05). The s-100β (0.29 ± 0.15 ) μg/L in the Sodium valproate group was lower versus the Carbamazepine group (0.54± 0.14) μg/L (P < 0.05). The TER of the Sodium valproate group (93.33% ) was higher versus the Carbamazepine group of 75% (P < 0 .0 5 ). The number of epileptic seizures in the Sodium valproate group was 0.81± 0.08 times per year versus 1.23± 0.12 times per year in the Carbamazepine group. The duration of epilepsy in the Sodium valproate group (2.53± 0.22 min/time) was shorter than that in the Carbamazepine group (3.08 ± 0.24 min/time). Conclusions: Sodium valproate can drastically relieve the epileptic symptoms of patients with SE, and there was no great difference in ARs. Hence, it is safe and worthy of popularization and application.

Indexed as

cytokinesIL-2IL-8s-100βsecondary epilepsyserum NSEsodium valproateTNF-α

Identifiers

PMID42770148

DOI10.5937/jomb0-55343

PMCPMC13592862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.