ArticleJournal of medical biochemistry2026
Serum levels of MMP3 could be used as a potential biomarker for sports-induced knee osteoarthritis.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Evaluating the potential biomarkers for diagnosing knee osteoarthritis caused by sports activities. Methods: This was a body-split case-control study. We identified 25 eligible participants for our research with no other knee procedures besides meniscus removal. For the determination of serum Glycosaminoglycan (GAG) and matrix metalloproteinase 3 (MMP-3) levels, blood was taken from 25 eligible individuals using 3 simple 6 mL EDTA vacutainer tubes. Patients also had knee aspirations, both surgical and non-surgical. Out of the 25 attempts, a successful knee synovial fluid aspirate was obtained. Additionally, all 25 attempts to get a contralateral control knee aspirate were successful. The raw values of the cohorts' demographics, radiological, clinical, PROMs, and biomarkers of MMP3 and GAG. Results: The duration of pain was 4.52 ± 0.85 and 5.85 ± 1.22 in non-operated and operated individuals, respectively. The VSA Pain score was 48.74 ± 2.87 and 53.55 ± 3.39, and the Lequesne algofunctional index was 11.02 ± 1.29 and 13.36 ± 1.57 in non-operated and operated participants, respectively. A comparative examination of MMP-3 levels in the synovial fluid showed that the levels of MMP3 remain notably elevated in the affected knees (p= 0.01). Additionally, synovial GAG levels in the affected knee joint were dramatically reduced (p= 0.03). An inverse connection was seen between the levels of MMP-3 and GAGs in the synovial fluid when analysing all 25 samples from both non-affected and affected knees. The correlation coefficient (r) was -0.88, indicating a strong negative relationship. The p-value was 0.04, suggesting statistical significance. Conclusions: Our results suggest that MMP3 serum levels may be a simple blood test away from becoming a diagnostic tool for knee osteoarthritis and a possible predictor of the disease. To better assess athletes' joint health, it may be helpful to combine biomarkers with other diagnostic tools and have a comprehensive understanding of their athletic background.
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