ArticleAvicenna journal of phytomedicine2026
Investigation of the effects of alcoholic frankincense extract on oxidative stress and inflammatory parameters in C57BL/6 mice with induced autoimmune encephalomyelitis.
Article in Avicenna journal of phytomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by neuroinflammation and demyelination. Frankincense, a natural oleo-gum-resin obtained from the genus Materials and Methods: Female C57BL/6 mice were randomly assigned to three groups (n = 5). Experimental autoimmune encephalomyelitis (EAE) was induced by subcutaneous immunization with MOG Results: EAE induction caused significant weight loss, severe clinical symptoms, increased IL-17A and IL-23 levels, reduced TGF-β and TAC, and marked neuroinflammation with myelin damage. Frankincense treatment significantly improved clinical scores and body weight, decreased proinflammatory cytokines, enhanced antioxidant capacity, and attenuated inflammatory infiltration and myelin degradation in brain tissue. Conclusion: Alcoholic frankincense extract ameliorated EAE-associated inflammation and oxidative stress and exerted a protective effect on myelin integrity, suggesting its potential as a complementary therapeutic approach for MS. Further studies are warranted to confirm its clinical applicability.
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