ArticleJournal of medical biochemistry2026
Oxidative stress and DNA damage profile in cord blood of vitamin B12-deficient newborns.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vitamin B12 is an essential biomolecule involved in DNA synthesis, epigenetic regulation, and energy metabolism. Maternal vitamin B12 deficiency during pregnancy has been linked to oxidative stress and impaired DNA integrity. This study aimed to investigate oxidative stress and DNA damage biomarkers in term newborns with vitamin B12 deficiency and to assess their diagnostic value. Methods: A single-centre, prospective case-control study was conducted in 48 term newborns with vitamin B12 deficiency and 40 matched healthy controls. Cord venous blood samples were analysed for vitamin B12, oxidative stress parameters, and a DNA damage marker. Diagnostic performance was evaluated by receiver operating characteristic analysis. Results: Vitamin B12 levels were markedly lower in the patient group than in controls. Newborns with vitamin B12 deficiency had significantly higher levels of 8-hydroxy-2'-deoxyguanosine, total oxidant status, and oxidative stress index, whereas total antioxidant status did not differ. Receiver operating characteristic analysis demonstrated the highest diagnostic accuracy for total oxidant status, followed by 8-hydroxy-2'-deoxyguanosine and oxidative stress index. Conclusions: Oxidative stress and DNA damage were clearly increased in vitamin B12-deficient newborns. These findings suggest that maternal vitamin B12 deficiency leaves detectable biochemical imprints at birth. This prospective analysis highlights that total oxidant status, oxidative stress index, and 8-hydroxy-2'-deoxyguanosine may serve as valuable diagnostic biomarkers and, to our knowledge, represents one of the few studies linking vitamin B12 deficiency to oxidative damage in newborns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.